Which of the following is a transmission route for sepsis?

Sepsis in neonates can indeed result from a transplacental transmission route. During pregnancy, infectious organisms can cross the placental barrier, leading to infections in the fetus. This can occur through various mechanisms, such as during maternal infections or through conditions like chorioamnionitis, where the membranes surrounding the fetus become infected. These pathogens can enter the fetal bloodstream, potentially leading to sepsis.

Understanding the mechanisms of transmission is vital in neonatal care, as it influences prenatal monitoring, maternal treatment, and the immediate care newborns receive after birth. The other options, while they may involve potential risks, do not specifically align with the primary transmission mechanisms associated with sepsis in neonates as directly as transplacental transmission does.